IgM Memory Cells: First Responders in Malaria

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC). Recent studies of MBC development and function after protein immunization have uncovered significant MBC heterogeneity. To clarify functional roles for distinct MBC subsets during malaria infection, we generated tetramers that identify Plasmodium-specific MBCs in ...

Resilience among first responders.

BACKGROUND Emergency rescue personnel can be considered a "high risk" occupational group in that they could experience a broad range of health and mental health consequences as a result of work-related exposures to critical incidents. OBJECTIVES This study examined the resilience factors that protect mental health among first responders. METHODS Nine hundred and sixty-one first responders f...

Human IgM+CD27+ B cells: memory B cells or "memory" B cells?

Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27-) B cells following stimulation in vitro, consistent with the heightened kinetics of secondary responses in vivo. CD27+ B cells expres...

VoiceLETS backs up first responders

Food Safety for First Responders

508 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 11, No. 3, March 2005 person-years) is substantially higher than the findings of Nennig and others (10) among an urban population in San Francisco (176 cases per 100,000 person-years). This finding may be due to the difference in immunization practices between Israel and the United States (5 doses of DTP vaccine in the United States with...